https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16959 -7), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05–1.32); meta-analysis p = 2.6×10-8). The nearby gene, MMP12, was significantly over expressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10-15; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p<0.001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS.]]> Wed 11 Apr 2018 17:21:31 AEST ]]> Wave reflection: More than a round trip https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43670 refl), and the augmentation index (AI), assuming a general extended model of the arterial system. Then, we test the proposed model against values reported in the literature. Finally, we discuss insights from the model to common observations in the literature such as age-related “shift” in the reflection site, the variation of AI with heart rate, and the flattening of Trefl in older participants.]]> Tue 27 Sep 2022 15:14:55 AEST ]]> The long-term relation among retinal arteriolar narrowing, blood pressure, and incident severe hypertension https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5222 Sat 24 Mar 2018 07:44:21 AEDT ]]> Microvascular flow, clinical illness severity and cardiovascular function in the preterm infant https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4348 Mon 08 Apr 2019 09:49:35 AEST ]]>